Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells
Passaes C, Desjardins D, Chapel A, Monceaux V, Lemaitre J, Mélard A, Perdomo-Celis F, Planchais C, Gourvès M, Dimant N, David A, Dereuddre-Bosquet N, Barrail-Tran A, Gouget H, Guillaume C, Relouzat F, Lambotte O, Guedj J, Müller-Trutwin M, Mouquet H, Rouzioux C, Avettand-Fenoël V, Le Grand R, Sáez-Cirión A. Nature…
Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller
Molinos-Albert LM, Baquero E, Bouvin-Pley M, Lorin V, Charre C, Planchais C, Dimitrov JD, Monceaux V, Vos M, Hocqueloux L, Berger J-L, Seaman MS, Braibant M, Avettand-Fenoël V, Sáez-Cirión A, Mouquet H Cell Host Microbe. 2023 Aug 9;31(8):1275-1287.e8
In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control
Trémeaux P, Lemoine F, Mélard A, Gousset M, Boufassa F, Orr S, Monceaux V, Gascuel O, Lambotte O, Hocqueloux L, Saez-Cirion A, Rouzioux C, Avettand-Fenoel V. Microbiol Spectr. 2023 Jan 24:e0326722.
Prolonged Antiretroviral Treatment Induces Adipose Tissue Remodelling Associated with Mild Inflammation in SIV-Infected Macaques.
Mausoléo A, Olivo A, Desjardins D, Sáez-Cirión A, Barrail-Tran A, Avettand-Fenoel V, Noël N, Lagathu C, Béréziat V, Le Grand R, Lambotte O, Bourgeois C. Cells. 2022 Oct 2;11(19):3104.
Isotopic Radiolabeling of the Antiretroviral Drug [18F]Dolutegravir for Pharmacokinetic PET Imaging.
Tisseraud M, Goutal S, Bonasera T, Goislard M, Desjardins D, Le Grand R, Parry CM, Tournier N, Kuhnast B, Caillé F Pharmaceuticals (Basel) 2022 May; 15(5): 587
Novel role of UHRF1 in the epigenetic repression of the latent HIV-1
Verdikt V, Bendoumou M, Bouchat S, Nestola L, Pasternak AO, Darcis G, Avettand-Fenoeld V, Vanhulle C, Aït-Ammar A, Santangelo M. Plant E, LeDouce V, Delacourt N, Cicilionytė A, Necsoi C, Corazza F, Passaes CPB, Schwartz C, Bizet M, Fuks F, Sáez-Cirión A, Rouzioux C, De Wit S, Berkhout B, Gautier…
Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers
Molinos-Albert LM, Lorin V, Monceaux V, Orr S, Essat A, Dufloo J, Schwartz O, Rouzioux C, Meyer L, Hocqueloux L, Sáez-Cirión A, Mouquet H & ANRS VISCONTI Study Group Nature Communications Vol 13 : 1944 (2022)
Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control.
Perdomo-Celis F, Passaes C, Monceaux V, Volant S, Boufassa F, de Truchis P, Marcou M, Bourdic K, Weiss L, Jung C, Bourgeois C, Goujard C, Meyer L, Müller-Trutwin M, Lambotte O, Sáez-Cirión A. J Clin Invest 2022, 132(11):e157549
Expansion of Immature Neutrophils During SIV Infection Is Associated With Their Capacity to Modulate T-Cell Function
Lemaitre J, Desjardins D, Gallouët AS, Gomez-Pacheco M, Bourgeois C, Favier B, Sáez-Cirión A, Le Grand R, Lambotte O. Front Immunol. 2022 Feb 3;13:781356. doi: 10.3389/fimmu.2022.781356. PMID: 35185880
Initiating antiretroviral treatment early in infancy has long-term benefits on the HIV reservoir in late childhood and adolescence.
Avettand-Fenoel V, Lechenadec J, Diallo MS, Fillion M, Melard A, Samri A, Dollfus C, Blanche S, Faye A, Amokrane K, Autran B, Buseyne F, Warszawski J, Frange P; ANRS-EP59-CLEAC Study Group. Clin Infect Dis. 2021 Dec 6;73(11):e4214-e4222. doi: 10.1093/cid/ciaa1931. PMID: 34355738.
Ultrasensitive Detection of p24 in Plasma Samples from People with Primary and Chronic HIV-1 Infection
Passaes C, Delagreverie HM, Avettand-Fenoel V, David A, Monceaux V, Essat A, Müller-Trutwin M, Duffy D, De Castro N, Wittkop L, Rouzioux C, Molina JM, Meyer L, Delaugerre C, Sáez-Cirión A. J Virol. 2021 Jun 24;95(14):e0001621. doi: 10.1128/JVI.00016-21. PMID: 33952636
CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues
Huot N, Rascle P, Planchais C, Contreras V, Passaes C, Le Grand R, Beignon AS, Kornobis E, Legendre R, Varet H, Saez-Cirion A, Mouquet H, Jacquelin B, Müller-Trutwin M. Front Immunol. 2021 Jun 16;12:695148. doi: 10.3389/fimmu.2021.695148. PMID: 34220857
Role of NKG2a/c+ CD8 + T cells in pathogenic versus non-pathogenic SIV infections
Huot N, Rascle P, Tchitchek N, Wimmer B, Passaes C, Contreras V, Desjardins D, Stahl-Hennig C, Le Grand R, Saez-Cirion A, Jacquelin B, Müller-Trutwin M. iScience. 2021 Mar 15;24(4):102314. doi: 10.1016/j.isci.2021.102314. PMID: 33870131
SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity
Huot N, Rascle P, Petitdemange C, Contreras V, Stürzel CM, Baquero E, Harper JL, Passaes C, Legendre R, Varet H, Madec Y, Sauermann U, Stahl-Hennig C, Nattermann J, Saez-Cirion A, Le Grand R, Keith Reeves R, Paiardini M, Kirchhoff F, Jacquelin B, Müller-Trutwin M. Nat Commun. 2021 Feb 24;12(1):1282. doi:…
Inhibition of HIV-1 gene transcription by KAP1 in myeloid lineage
Ait-Ammar A, Bellefroid M, Daouad F, Martinelli V, Van Assche J, Wallet C, Rodari A, De Rovere M, Fahrenkrog B, Schwartz C, Van Lint C, Gautier V, Rohr O. Sci Rep. 2021 Jan 29;11(1):2692. doi: 10.1038/s41598-021-82164-w.PMID: 33514850
Optimal Maturation of the SIV-Specific CD8 + T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study
Passaes C, Millet A, Madelain V, Monceaux V, David A, Versmisse P, Sylla N, Gostick E, Llewellyn-Lacey S, Price DA, Blancher A, Dereuddre-Bosquet N, Desjardins D, Pancino G, Le Grand R, Lambotte O, Müller-Trutwin M, Rouzioux C, Guedj J, Avettand-Fenoel V, Vaslin B, Sáez-Cirión A. Cell Rep. 2020 Sep 22;32(12):108174….
Immunometabolism and HIV-1 pathogenesis: food for thought.
Sáez-Cirión A, Sereti I (2021). Nat Rev Immunol., 21(1):5-19. doi: 10.1038/s41577-020-0381-7.
Antiapoptotic Clone 11-Derived Peptides Induce In Vitro Death of CD4+ T Cells Susceptible to HIV-1 Infection
Mikhailova A, Valle-Casuso JC, David A, Monceaux V, Volant S, Passaes C, Elfidha A, Müller-Trutwin M, Poyet JL, Sáez-Cirión A. J Virol. 2020 Jul 1;94(14):e00611-20. doi: 10.1128/JVI.00611-20. PMID: 32350074
Characterization of Physicians That Might Be Reluctant to Propose HIV Cure-Related Clinical Trials with Treatment Interruption to Their Patients? The ANRS-APSEC Study.
Protiere C, Fressard L, Mora M, Meyer L, Préau M, Suzan-Monti M, Lelièvre JD, Lambotte O, Spire B, Vaccines (Basel). 2020 Jun 23;8(2):334.
Extremely low viral reservoir in treated chronically HIV-1-infected individuals
Gálvez C, Urrea V, Dalmau J, Jimenez M, Clotet B, Monceaux V, Huot N, Leal L, González-Soler V, González-Cao M, Müller-Trutwin M, Sáez-Cirión A, García F, Blanco J, Martinez-Picado J, Salgado M. EBioMedicine. 2020 Jul;57:102830. doi: 10.1016/j.ebiom.2020.102830. PMID: 32580136
Who are the persons living with HIV who might refuse to participate in HIV cure-related clinical trials with treatment interruption?
Protiere C, Fiorentino M, Sow A, Préau M, Mora M, Fressard L, Meyer L, Lelièvre JD, Lambotte O, Spire B, Suzan-Monti M. AIDS. 2020 Jun 1;34(7):1095-1099. doi: 10.1097/QAD.0000000000002530. PMID: 32287066.
Mass Cytometry Reveals the Immaturity of Circulating Neutrophils during SIV Infection
Lemaitre J, Cosma A, Desjardins D, Lambotte O, Le Grand R. J Innate Immun. 2020;12(2):170-181. doi: 10.1159/000499841. Epub 2019 Jun 21. PMID: 31230057; PMCID: PMC7103026.
Differences in HIV cure clinical trial preferences of French people living with HIV and physicians in the ANRS-APSEC study: a discrete choice experiment.
Protiere C, Arnold M, Fiorentino M, Fressard L, Lelièvre JD, Mimi M, Raffi F, Mora M, Meyer L, Sagaon-Teyssier L, Zucman D, Préau M, Lambotte O, Spire B, Suzan-Monti M J Int AIDS Soc. 2020 Feb;23(2):e25443
Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells
V. Madelain, C. Passaes, A. Millet, V. Avettand-Fenoel, R. Djidjou-Demasse, N. Dereuddre-Bosquet, R. Le Grand, C. Rouzioux, B. Vaslin, A. Saez-Cirion, J. Guedj. doi: https://doi.org/10.1101/2020.01.19.911594
Metabolic plasticity of HIV-specific CD8 + T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection
Angin M, Volant S, Passaes C, Lecuroux C, Monceaux V, Dillies MA, Valle-Casuso JC, Pancino G, Vaslin B, Le Grand R, Weiss L, Goujard C, Meyer L, Boufassa F, Müller-Trutwin M, Lambotte O, Sáez-Cirión A. Nat Metab. 2019 Jul;1(7):704-716. doi: 10.1038/s42255-019-0081-4. Epub 2019 Jul 12. PMID: 32694646.
The Yellow Brick Road towards HIV Eradication
Saez-Cirion A, Müller-Trutwin M. Trends Immunol. 2019 Jun;40(6):465-467. doi: 10.1016/j.it.2019.04.006. Epub 2019 May 6. PMID: 31072685.
Increasing contribution of integrated forms to total HIV DNA in blood during HIV disease progression from primary infection.
Trémeaux P, Lenfant T, Boufassa F, Essat A, Mélard A, Gousset M, Delelis O, Viard JP, Bary M, Goujard C, Rouzioux C, Meyer L, Avettand-Fenoel V; ANRS-SEROCO and PRIMO cohorts. EBioMedicine. 2019 Mar;41:455-464. doi: 10.1016/j.ebiom.2019.02.016. Epub 2019 Feb 23. PMID: 30803934; PMCID: PMC6442355.
Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4 + T Cells and Offers an Opportunity to Tackle Infection
Valle-Casuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, Bourdic K, Avettand-Fenoel V, Boufassa F, Sitbon M, Lambotte O, Thoulouze MI, Müller-Trutwin M, Chomont N, Sáez-Cirión A. Cell Metab. 2019 Mar 5;29(3):611-626.e5. doi: 10.1016/j.cmet.2018.11.015. Epub 2018 Dec 20. PMID: 30581119.
Dynamics in HIV DNA levels over time in HIV Controllers.
Avettand-Fenoel V, Bayan T, Gardiennet E, Boufassa F, Lopez P, Lecuroux C, Noel N, Trémeaux P, Monceaux V, Autran B, Meyer L, Saez-Cirion A, Lambotte O, Rouzioux C; CODEX ANRS Cohort Study Group. J Int AIDS Soc. 2019 Jan;22(1):e25221. doi: 10.1002/jia2.25221. PMID: 30629340; PMCID: PMC6327944.
HIV DNA: a clinical marker of HIV reservoirs
Rouzioux C, Trémeaux P, Avettand-Fenoël V. Curr Opin HIV AIDS 2018 Sep;13(5):389-394. doi: 10.1097/COH.0000000000000483. PMID: 30020275.
Cellular Determinants of HIV Persistence on Antiretroviral Therapy
Mikhailova A, Valle-Casuso JC, Sáez-Cirión A. Adv Exp Med Biol. 2018;1075:213-239. doi: 10.1007/978-981-13-0484-2_9. PMID: 30030795.
Total HIV DNA: a global marker of HIV persistence
Rouzioux C, Avettand-Fenoël V. 2018 Apr 3;15(1):30. doi: 10.1186/s12977-018-0412-7. PMID: 29615133; PMCID: PMC5883363.
Will CURE trials introduce an uncomfortable revolution in the field of HIV research?
Protière C, Préau M, Doumergue M, Mora M, Lambotte O, Spire B, Suzan-Monti M HIV Clin Trials. 2017 Jul;18(4):174-175.
Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents
Passaes CPB, Bruel T, Decalf J, David A, Angin M, Monceaux V, Muller-Trutwin M, Noel N, Bourdic K, Lambotte O, Albert ML, Duffy D, Schwartz O, Sáez-Cirión A. J Virol. 2017 Feb 28;91(6):e02296-16. doi: 10.1128/JVI.02296-16. PMID: 28077644; PMCID: PMC5331803.
Comprehensive Mass Cytometry Analysis of Cell Cycle, Activation, and Coinhibitory Receptors Expression in CD4 T Cells from Healthy and HIV-Infected Individuals
Corneau A, Cosma A, Even S, Katlama C, Le Grand R, Frachet V, Blanc C, Autran B. Cytometry B Clin Cytom. 2017 Jan;92(1):21-32. doi: 10.1002/cyto.b.21502. Erratum in: Cytometry B Clin Cytom. 2017 May;92 (3):236-237. PMID: 27997758.
Patterns of patient and healthcare provider viewpoints regarding participation in HIV cure-related clinical trials. Findings from a multicentre French survey using Q methodology (ANRS-APSEC).
Protière C, Spire B, Mora M, Poizot-Martin I, Préau M, Doumergue M, Morlat P, Zucman D, Goujard C, Raffi F, Lambotte O, Suzan-Monti M. PLoS One. 2017 Nov 2;12(11):e0187489.
Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications
Avettand-Fènoël V, Hocqueloux L, Ghosn J, Cheret A, Frange P, Melard A, Viard JP, Rouzioux C. Clin Microbiol Rev. 2016 Oct;29(4):859-80. doi: 10.1128/CMR.00015-16. PMID: 27559075; PMCID: PMC5010749.
HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report
Frange P, Faye A, Avettand-Fenoël V, Bellaton E, Descamps D, Angin M, David A, Caillat-Zucman S, Peytavin G, Dollfus C, Le Chenadec J, Warszawski J, Rouzioux C, Sáez-Cirión A; ANRS EPF-CO10 Pediatric Cohort and the ANRS EP47 VISCONTI study group. Lancet HIV. 2016 Jan;3(1):e49-54. doi: 10.1016/S2352-3018(15)00232-5. Epub 2015 Dec 9….
Intensive five-drug antiretroviral therapy regimen versus standard triple-drug therapy during primary HIV-1 infection (OPTIPRIM-ANRS 147): a randomised, open-label, phase 3 trial
Chéret A, Nembot G, Mélard A, Lascoux C, Slama L, Miailhes P, Yeni P, Abel S, Avettand-Fenoel V, Venet A, Chaix ML, Molina JM, Katlama C, Goujard C, Tamalet C, Raffi F, Lafeuillade A, Reynes J, Ravaux I, Hoën B, Delfraissy JF, Meyer L, Rouzioux C; OPTIPRIM ANRS Study Group….
Long-term antiretroviral therapy initiated during primary HIV-1 infection is key to achieving both low HIV reservoirs and normal T cell counts
Hocqueloux L, Avettand-Fènoël V, Jacquot S, Prazuck T, Legac E, Mélard A, Niang M, Mille C, Le Moal G, Viard JP, Rouzioux C; AC32 (Coordinated Action on HIV Reservoirs) of the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS). J Antimicrob Chemother. 2013 May;68(5):1169-78. doi: 10.1093/jac/dks533….
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C; ANRS VISCONTI Study Group. PLoS Pathog….