Aurélie Tran-Barrail

People in remission of HIV infection have benefited from therapies that limited the size of viral reservoir, contributing to preventing post-treatment rebound of viremia. Early control of this reservoir, limitation of pharmacological sanctuaries and residual replication that can be improved by direct antiviral effects are among the key scientific challenges to make remission a reality… Continue reading Imaging drug diffusion and viral reservoirs, WP2

Early ART initiation seems to favor post-treatment control of infection. However, only a minority of the individuals who are treated early is able to control viremia once the treatment is interrupted. Through retrospective analyses of data available in the ANRS CO6 PRIMO cohort and the Post-treatment controllers in the ANRS VISCONTI study, we have identified… Continue reading ANRS 175 RHIVIERA 01_Assessment of HIV remission upon ART interruption in early treated individuals from ANRS CO6 PRIMO cohort carrying the MHC genotype B35(53)Bw4TTC2

ART initiation during primary HIV infection limits the establishment, diversity and distribution of the viral reservoir while preserving key lymphoid organs of the deleterious effects of persistent viral replication and chronic immune activation, favoring the optimal maturation of immune responses. Early ART initiation may even facilitate long-term post-treatment control in some individuals. Therapeutic interventions during… Continue reading ANRS 176 RHIVIERA 02_Assessment of HIV remission upon ART interruption in individuals initiating ART in combination with two long lasting bNabs during primary infection