About

IDMIT executive director and head of the division of Immuno-Virology at CEA (Fontenay-aux-Roses). His research focuses on understanding the HIV-infection pathogenesis, viral dynamics and persistence, the innate, cellular, and humoral immune responses, the prevention of HIV transmission, and the development/evaluation of innovative HIV vaccine strategies.

Position
Researcher
Institution
CEA (IDMIT)

Linked Projects

Funded Research Project

Title: A Non-Human Primate Model For HIV Remission (pVISCONTI)

The VISCONTI study proposed that post-treatment control (PTC) of HIV infection might be favored by early antiretroviral treatment (ART) initiation. However, a formal demonstration has not been established and the underlying mechanisms leading to PTC remain elusive. The pVISCONTI program aims to assess, in standardized conditions, the impact of early versus late ART initiation on… Continue reading A Non-Human Primate Model For HIV Remission (pVISCONTI)

Country
France
Starting year
2016
Duration
7 years
Budget
5.2M€
Members/PIs involved
Read more
Funded Research Project

Title: Fine characterization of the latent HIV-1/SIV reservoirs using a highly multiplex innovative approach

The development of therapeutic strategies towards HIV cure requires first an appropriate definition of the latent HIV reservoirs in which HIV persists indefinitely as a barrier against cure. Therefore, a correct redefinition of cells harboring the latent reservoirs is key to define the appropriate signals and drugs that would help at purging the HIV reservoirs.… Continue reading Fine characterization of the latent HIV-1/SIV reservoirs using a highly multiplex innovative approach

Country
France
Starting year
2016
Duration
3 years
Budget
110K€
Members/PIs involved
Read more
Funded Research Project

Title: Imaging drug diffusion and viral reservoirs, WP2

People in remission of HIV infection have benefited from therapies that limited the size of viral reservoir, contributing to preventing post-treatment rebound of viremia. Early control of this reservoir, limitation of pharmacological sanctuaries and residual replication that can be improved by direct antiviral effects are among the key scientific challenges to make remission a reality… Continue reading Imaging drug diffusion and viral reservoirs, WP2

Country
France
Starting year
2019
Duration
3 years
Budget
1.5M€
Members/PIs involved
Read more

Linked Publications

Isotopic Radiolabeling of the Antiretroviral Drug [18F]Dolutegravir for Pharmacokinetic PET Imaging.

Tisseraud M, Goutal S, Bonasera T, Goislard M, Desjardins D, Le Grand R, Parry CM, Tournier N, Kuhnast B, Caillé F

Pharmaceuticals (Basel) 2022 May; 15(5): 587

Role of NKG2a/c+ CD8 + T cells in pathogenic versus non-pathogenic SIV infections

Huot N, Rascle P, Tchitchek N, Wimmer B, Passaes C, Contreras V, Desjardins D, Stahl-Hennig C, Le Grand R, Saez-Cirion A, Jacquelin B, Müller-Trutwin M. iScience. 2021 Mar 15;24(4):102314. doi: 10.1016/j.isci.2021.102314. PMID: 33870131

Expansion of Immature Neutrophils During SIV Infection Is Associated With Their Capacity to Modulate T-Cell Function

Lemaitre J, Desjardins D, Gallouët AS, Gomez-Pacheco M, Bourgeois C, Favier B, Sáez-Cirión A, Le Grand R, Lambotte O. Front Immunol. 2022 Feb 3;13:781356. doi: 10.3389/fimmu.2022.781356. PMID: 35185880 

CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues

Huot N, Rascle P, Planchais C, Contreras V, Passaes C, Le Grand R, Beignon AS, Kornobis E, Legendre R, Varet H, Saez-Cirion A, Mouquet H, Jacquelin B, Müller-Trutwin M. Front Immunol. 2021 Jun 16;12:695148. doi: 10.3389/fimmu.2021.695148. PMID: 34220857 

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

Huot N, Rascle P, Petitdemange C, Contreras V, Stürzel CM, Baquero E, Harper JL, Passaes C, Legendre R, Varet H, Madec Y, Sauermann U, Stahl-Hennig C, Nattermann J, Saez-Cirion A, Le Grand R, Keith Reeves R, Paiardini M, Kirchhoff F, Jacquelin B, Müller-Trutwin M. Nat Commun. 2021 Feb 24;12(1):1282. doi: 10.1038/s41467-021-21402-1.PMID: 33627642

Optimal Maturation of the SIV-Specific CD8 + T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study

Passaes C, Millet A, Madelain V, Monceaux V, David A, Versmisse P, Sylla N, Gostick E, Llewellyn-Lacey S, Price DA, Blancher A, Dereuddre-Bosquet N, Desjardins D, Pancino G, Le Grand R, Lambotte O, Müller-Trutwin M, Rouzioux C, Guedj J, Avettand-Fenoel V, Vaslin B, Sáez-Cirión A. Cell Rep. 2020 Sep 22;32(12):108174. doi: 10.1016/j.celrep.2020.108174. PMID: 32966788.

Mass Cytometry Reveals the Immaturity of Circulating Neutrophils during SIV Infection

Lemaitre J, Cosma A, Desjardins D, Lambotte O, Le Grand R. J Innate Immun. 2020;12(2):170-181. doi: 10.1159/000499841. Epub 2019 Jun 21. PMID: 31230057; PMCID: PMC7103026.

Modeling SIV kinetics supports that cytotoxic response drives natural control and unravels heterogeneous populations of infected cells

V. Madelain, C. Passaes, A. Millet, V. Avettand-Fenoel, R. Djidjou-Demasse, N. Dereuddre-Bosquet, R. Le Grand, C. Rouzioux, B. Vaslin, A. Saez-Cirion, J. Guedj. doi: https://doi.org/10.1101/2020.01.19.911594

Metabolic plasticity of HIV-specific CD8 + T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection

Angin M, Volant S, Passaes C, Lecuroux C, Monceaux V, Dillies MA, Valle-Casuso JC, Pancino G, Vaslin B, Le Grand R, Weiss L, Goujard C, Meyer L, Boufassa F, Müller-Trutwin M, Lambotte O, Sáez-Cirión A. Nat Metab. 2019 Jul;1(7):704-716. doi: 10.1038/s42255-019-0081-4. Epub 2019 Jul 12. PMID: 32694646.

Comprehensive Mass Cytometry Analysis of Cell Cycle, Activation, and Coinhibitory Receptors Expression in CD4 T Cells from Healthy and HIV-Infected Individuals

Corneau A, Cosma A, Even S, Katlama C, Le Grand R, Frachet V, Blanc C, Autran B. Cytometry B Clin Cytom. 2017 Jan;92(1):21-32. doi: 10.1002/cyto.b.21502. Erratum in: Cytometry B Clin Cytom. 2017 May;92 (3):236-237. PMID: 27997758.