Professor of Internal Medicine at Kremlin-Bicêtre hospital. On the aims of his research is the characterization of HIV reservoirs, HIV persistence, and deciphering latency reactivation mechanisms and latency-reactivating agents (LRAs). He specializes in HIV-related clinical trials, in particular, the epidemiology and clinical characteristics of HIV-controllers (individuals infected with HIV who can spontaneously control viremia to maintain very low viral loads).
The VISCONTI study proposed that post-treatment control (PTC) of HIV infection might be favored by early antiretroviral treatment (ART) initiation. However, a formal demonstration has not been established and the underlying mechanisms leading to PTC remain elusive. The pVISCONTI program aims to assess, in standardized conditions, the impact of early versus late ART initiation on… Continue reading A Non-Human Primate Model For HIV Remission (pVISCONTI)
Despite current effective and life-prolonging combination antiretroviral therapy (ART), HIV 1 can still not be cured and remission is not attainable for most persons. Indeed, the virus persists in people receiving ART and can produce active infection upon treatment interruption due notably to reactivation of viral expression from latently-infected cells, called HIV reservoirs. HIV-1 transcriptional… Continue reading Heterogeneity of mechanisms responsible for HIV-1 gene silencing, WP1
Trémeaux P, Lemoine F, Mélard A, Gousset M, Boufassa F, Orr S, Monceaux V, Gascuel O, Lambotte O, Hocqueloux L, Saez-Cirion A, Rouzioux C, Avettand-Fenoel V.
Microbiol Spectr. 2023 Jan 24:e0326722.
Lemaitre J, Desjardins D, Gallouët AS, Gomez-Pacheco M, Bourgeois C, Favier B, Sáez-Cirión A, Le Grand R, Lambotte O. Front Immunol. 2022 Feb 3;13:781356. doi: 10.3389/fimmu.2022.781356. PMID: 35185880
Passaes C, Millet A, Madelain V, Monceaux V, David A, Versmisse P, Sylla N, Gostick E, Llewellyn-Lacey S, Price DA, Blancher A, Dereuddre-Bosquet N, Desjardins D, Pancino G, Le Grand R, Lambotte O, Müller-Trutwin M, Rouzioux C, Guedj J, Avettand-Fenoel V, Vaslin B, Sáez-Cirión A. Cell Rep. 2020 Sep 22;32(12):108174. doi: 10.1016/j.celrep.2020.108174. PMID: 32966788.
Protiere C, Fiorentino M, Sow A, Préau M, Mora M, Fressard L, Meyer L, Lelièvre JD, Lambotte O, Spire B, Suzan-Monti M. AIDS. 2020 Jun 1;34(7):1095-1099. doi: 10.1097/QAD.0000000000002530. PMID: 32287066.
Lemaitre J, Cosma A, Desjardins D, Lambotte O, Le Grand R. J Innate Immun. 2020;12(2):170-181. doi: 10.1159/000499841. Epub 2019 Jun 21. PMID: 31230057; PMCID: PMC7103026.
Angin M, Volant S, Passaes C, Lecuroux C, Monceaux V, Dillies MA, Valle-Casuso JC, Pancino G, Vaslin B, Le Grand R, Weiss L, Goujard C, Meyer L, Boufassa F, Müller-Trutwin M, Lambotte O, Sáez-Cirión A. Nat Metab. 2019 Jul;1(7):704-716. doi: 10.1038/s42255-019-0081-4. Epub 2019 Jul 12. PMID: 32694646.
Valle-Casuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, Bourdic K, Avettand-Fenoel V, Boufassa F, Sitbon M, Lambotte O, Thoulouze MI, Müller-Trutwin M, Chomont N, Sáez-Cirión A. Cell Metab. 2019 Mar 5;29(3):611-626.e5. doi: 10.1016/j.cmet.2018.11.015. Epub 2018 Dec 20. PMID: 30581119.
Passaes CPB, Bruel T, Decalf J, David A, Angin M, Monceaux V, Muller-Trutwin M, Noel N, Bourdic K, Lambotte O, Albert ML, Duffy D, Schwartz O, Sáez-Cirión A. J Virol. 2017 Feb 28;91(6):e02296-16. doi: 10.1128/JVI.02296-16. PMID: 28077644; PMCID: PMC5331803.
Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C; ANRS VISCONTI Study Group. PLoS Pathog. 2013 Mar;9(3):e1003211. doi: 10.1371/journal.ppat.1003211. Epub 2013 Mar 14. PMID: 23516360; PMCID: PMC3597518.
Perdomo-Celis F, Passaes C, Monceaux V, Volant S, Boufassa F, de Truchis P, Marcou M, Bourdic K, Weiss L, Jung C, Bourgeois C, Goujard C, Meyer L, Müller-Trutwin M, Lambotte O, Sáez-Cirión A.
J Clin Invest 2022, 132(11):e157549
Avettand-Fenoel V, Bayan T, Gardiennet E, Boufassa F, Lopez P, Lecuroux C, Noel N, Trémeaux P, Monceaux V, Autran B, Meyer L, Saez-Cirion A, Lambotte O, Rouzioux C; CODEX ANRS Cohort Study Group. J Int AIDS Soc. 2019 Jan;22(1):e25221. doi: 10.1002/jia2.25221. PMID: 30629340; PMCID: PMC6327944.
Mausoléo A, Olivo A, Desjardins D, Sáez-Cirión A, Barrail-Tran A, Avettand-Fenoel V, Noël N, Lagathu C, Béréziat V, Le Grand R, Lambotte O, Bourgeois C.
Cells. 2022 Oct 2;11(19):3104.
Protière C, Spire B, Mora M, Poizot-Martin I, Préau M, Doumergue M, Morlat P, Zucman D, Goujard C, Raffi F, Lambotte O, Suzan-Monti M.
PLoS One. 2017 Nov 2;12(11):e0187489.
Protière C, Préau M, Doumergue M, Mora M, Lambotte O, Spire B, Suzan-Monti M
HIV Clin Trials. 2017 Jul;18(4):174-175.
Protiere C, Arnold M, Fiorentino M, Fressard L, Lelièvre JD, Mimi M, Raffi F, Mora M, Meyer L, Sagaon-Teyssier L, Zucman D, Préau M, Lambotte O, Spire B, Suzan-Monti M
J Int AIDS Soc. 2020 Feb;23(2):e25443
Protiere C, Fressard L, Mora M, Meyer L, Préau M, Suzan-Monti M, Lelièvre JD, Lambotte O, Spire B,
Vaccines (Basel). 2020 Jun 23;8(2):334.
Passaes C, Desjardins D, Chapel A, Monceaux V, Lemaitre J, Mélard A, Perdomo-Celis F, Planchais C, Gourvès M, Dimant N, David A, Dereuddre-Bosquet N, Barrail-Tran A, Gouget H, Guillaume C, Relouzat F, Lambotte O, Guedj J, Müller-Trutwin M, Mouquet H, Rouzioux C, Avettand-Fenoël V, Le Grand R, Sáez-Cirión A.
Nature Communications. 2024, 15(1), Article number: 178