Professor of Internal Medicine at Kremlin-Bicêtre hospital. On the aims of his research is the characterization of HIV reservoirs, HIV persistence, and deciphering latency reactivation mechanisms and latency-reactivating agents (LRAs). He specializes in HIV-related clinical trials, in particular, the epidemiology and clinical characteristics of HIV-controllers (individuals infected with HIV who can spontaneously control viremia to maintain very low viral loads).

Kremlin-Bicêtre Hospital

Linked Projects

Funded Research Project

Title: A Non-Human Primate Model For HIV Remission (pVISCONTI)

The VISCONTI study proposed that post-treatment control (PTC) of HIV infection might be favored by early antiretroviral treatment (ART) initiation. However, a formal demonstration has not been established and the underlying mechanisms leading to PTC remain elusive. The pVISCONTI program aims to assess, in standardized conditions, the impact of early versus late ART initiation on… Continue reading A Non-Human Primate Model For HIV Remission (pVISCONTI)

Starting year
7 years
Members/PIs involved
Read more
Funded Research Project

Title: Heterogeneity of mechanisms responsible for HIV-1 gene silencing, WP1

Despite current effective and life-prolonging combination antiretroviral therapy (ART), HIV 1 can still not be cured and remission is not attainable for most persons. Indeed, the virus persists in people receiving ART and can produce active infection upon treatment interruption due notably to reactivation of viral expression from latently-infected cells, called HIV reservoirs. HIV-1 transcriptional… Continue reading Heterogeneity of mechanisms responsible for HIV-1 gene silencing, WP1

Starting year
3 years
Members/PIs involved
Read more

Linked Publications

In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control

Trémeaux P, Lemoine F, Mélard A, Gousset M, Boufassa F, Orr S, Monceaux V, Gascuel O, Lambotte O, Hocqueloux L, Saez-Cirion A, Rouzioux C, Avettand-Fenoel V.

Microbiol Spectr. 2023 Jan 24:e0326722.

Expansion of Immature Neutrophils During SIV Infection Is Associated With Their Capacity to Modulate T-Cell Function

Lemaitre J, Desjardins D, Gallouët AS, Gomez-Pacheco M, Bourgeois C, Favier B, Sáez-Cirión A, Le Grand R, Lambotte O. Front Immunol. 2022 Feb 3;13:781356. doi: 10.3389/fimmu.2022.781356. PMID: 35185880 

Optimal Maturation of the SIV-Specific CD8 + T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study

Passaes C, Millet A, Madelain V, Monceaux V, David A, Versmisse P, Sylla N, Gostick E, Llewellyn-Lacey S, Price DA, Blancher A, Dereuddre-Bosquet N, Desjardins D, Pancino G, Le Grand R, Lambotte O, Müller-Trutwin M, Rouzioux C, Guedj J, Avettand-Fenoel V, Vaslin B, Sáez-Cirión A. Cell Rep. 2020 Sep 22;32(12):108174. doi: 10.1016/j.celrep.2020.108174. PMID: 32966788.

Who are the persons living with HIV who might refuse to participate in HIV cure-related clinical trials with treatment interruption?

Protiere C, Fiorentino M, Sow A, Préau M, Mora M, Fressard L, Meyer L, Lelièvre JD, Lambotte O, Spire B, Suzan-Monti M. AIDS. 2020 Jun 1;34(7):1095-1099. doi: 10.1097/QAD.0000000000002530. PMID: 32287066.

Mass Cytometry Reveals the Immaturity of Circulating Neutrophils during SIV Infection

Lemaitre J, Cosma A, Desjardins D, Lambotte O, Le Grand R. J Innate Immun. 2020;12(2):170-181. doi: 10.1159/000499841. Epub 2019 Jun 21. PMID: 31230057; PMCID: PMC7103026.

Metabolic plasticity of HIV-specific CD8 + T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection

Angin M, Volant S, Passaes C, Lecuroux C, Monceaux V, Dillies MA, Valle-Casuso JC, Pancino G, Vaslin B, Le Grand R, Weiss L, Goujard C, Meyer L, Boufassa F, Müller-Trutwin M, Lambotte O, Sáez-Cirión A. Nat Metab. 2019 Jul;1(7):704-716. doi: 10.1038/s42255-019-0081-4. Epub 2019 Jul 12. PMID: 32694646.

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4 + T Cells and Offers an Opportunity to Tackle Infection

Valle-Casuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, Bourdic K, Avettand-Fenoel V, Boufassa F, Sitbon M, Lambotte O, Thoulouze MI, Müller-Trutwin M, Chomont N, Sáez-Cirión A. Cell Metab. 2019 Mar 5;29(3):611-626.e5. doi: 10.1016/j.cmet.2018.11.015. Epub 2018 Dec 20. PMID: 30581119.

Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents

Passaes CPB, Bruel T, Decalf J, David A, Angin M, Monceaux V, Muller-Trutwin M, Noel N, Bourdic K, Lambotte O, Albert ML, Duffy D, Schwartz O, Sáez-Cirión A. J Virol. 2017 Feb 28;91(6):e02296-16. doi: 10.1128/JVI.02296-16. PMID: 28077644; PMCID: PMC5331803.

Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study

Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C; ANRS VISCONTI Study Group. PLoS Pathog. 2013 Mar;9(3):e1003211. doi: 10.1371/journal.ppat.1003211. Epub 2013 Mar 14. PMID: 23516360; PMCID: PMC3597518.

Dynamics in HIV DNA levels over time in HIV Controllers.

Avettand-Fenoel V, Bayan T, Gardiennet E, Boufassa F, Lopez P, Lecuroux C, Noel N, Trémeaux P, Monceaux V, Autran B, Meyer L, Saez-Cirion A, Lambotte O, Rouzioux C; CODEX ANRS Cohort Study Group. J Int AIDS Soc. 2019 Jan;22(1):e25221. doi: 10.1002/jia2.25221. PMID: 30629340; PMCID: PMC6327944.

Prolonged Antiretroviral Treatment Induces Adipose Tissue Remodelling Associated with Mild Inflammation in SIV-Infected Macaques.

Mausoléo A, Olivo A, Desjardins D, Sáez-Cirión A, Barrail-Tran A, Avettand-Fenoel V, Noël N, Lagathu C, Béréziat V, Le Grand R, Lambotte O, Bourgeois C.

Cells. 2022 Oct 2;11(19):3104. 

Patterns of patient and healthcare provider viewpoints regarding participation in HIV cure-related clinical trials. Findings from a multicentre French survey using Q methodology (ANRS-APSEC).

Protière C, Spire B, Mora M, Poizot-Martin I, Préau M, Doumergue M, Morlat P, Zucman D, Goujard C, Raffi F, Lambotte O, Suzan-Monti M.

PLoS One. 2017 Nov 2;12(11):e0187489.

Will CURE trials introduce an uncomfortable revolution in the field of HIV research?

Protière C, Préau M, Doumergue M, Mora M, Lambotte O, Spire B, Suzan-Monti M

HIV Clin Trials. 2017 Jul;18(4):174-175.

Differences in HIV cure clinical trial preferences of French people living with HIV and physicians in the ANRS-APSEC study: a discrete choice experiment.

Protiere C, Arnold M, Fiorentino M, Fressard L, Lelièvre JD, Mimi M, Raffi F, Mora M, Meyer L, Sagaon-Teyssier L, Zucman D, Préau M, Lambotte O, Spire B, Suzan-Monti M

 J Int AIDS Soc. 2020 Feb;23(2):e25443

Characterization of Physicians That Might Be Reluctant to Propose HIV Cure-Related Clinical Trials with Treatment Interruption to Their Patients? The ANRS-APSEC Study.

Protiere C, Fressard L, Mora M, Meyer L, Préau M, Suzan-Monti M, Lelièvre JD, Lambotte O, Spire B,

Vaccines (Basel). 2020 Jun 23;8(2):334.

Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells

Passaes C, Desjardins D, Chapel A, Monceaux V, Lemaitre J, Mélard A, Perdomo-Celis F, Planchais C, Gourvès M, Dimant N, David A, Dereuddre-Bosquet N, Barrail-Tran A, Gouget H, Guillaume C, Relouzat F, Lambotte O, Guedj J, Müller-Trutwin M, Mouquet H, Rouzioux C, Avettand-Fenoël V, Le Grand R, Sáez-Cirión A.

Nature Communications. 2024, 15(1), Article number: 178