Head of the HIV, Inflammation and Persistence unit at the Pasteur Institute (Paris). Her research focuses on deciphering the early host immune responses to identify factors involved in the protection against chronic inflammation and control of viral reservoirs in SIV and HIV-1 infections with the aim to translate the findings into clinical HIV research. She specializes in the studies of innate immunity (NK cells, plasmacytoid dendritic cells, myeloid cells, IFN-a), tissue viral reservoirs (intestine, secondary lymphoid organs) as well as in pre-clinical and clinical therapeutic trials.

Institut Pasteur

Linked Projects

Funded Research Project

Title: Viral dynamics of rebound and control following early treatment of HIV/SIV (NIH)

The results of the ANRS EP47 VISCONTI (Viro-Immunological Sustained COntrol after Treatment Interruption) study provided proof of concept that a state of sustainable HIV remission may be induced in at least some people with HIV: the post-treatment controllers (PTC). Unlike natural controllers, PTCs presented a symptomatic primary HIV-1 infection with high viral load and low… Continue reading Viral dynamics of rebound and control following early treatment of HIV/SIV (NIH)

Starting year
5 years
Members/PIs involved
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Funded Research Project

Title: A Non-Human Primate Model For HIV Remission (pVISCONTI)

The VISCONTI study proposed that post-treatment control (PTC) of HIV infection might be favored by early antiretroviral treatment (ART) initiation. However, a formal demonstration has not been established and the underlying mechanisms leading to PTC remain elusive. The pVISCONTI program aims to assess, in standardized conditions, the impact of early versus late ART initiation on… Continue reading A Non-Human Primate Model For HIV Remission (pVISCONTI)

Starting year
7 years
Members/PIs involved
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Linked Publications

Extremely low viral reservoir in treated chronically HIV-1-infected individuals

Gálvez C, Urrea V, Dalmau J, Jimenez M, Clotet B, Monceaux V, Huot N, Leal L, González-Soler V, González-Cao M, Müller-Trutwin M, Sáez-Cirión A, García F, Blanco J, Martinez-Picado J, Salgado M. EBioMedicine. 2020 Jul;57:102830. doi: 10.1016/j.ebiom.2020.102830. PMID: 32580136 

Antiapoptotic Clone 11-Derived Peptides Induce In Vitro Death of CD4+ T Cells Susceptible to HIV-1 Infection

Mikhailova A, Valle-Casuso JC, David A, Monceaux V, Volant S, Passaes C, Elfidha A, Müller-Trutwin M, Poyet JL, Sáez-Cirión A. J Virol. 2020 Jul 1;94(14):e00611-20. doi: 10.1128/JVI.00611-20. PMID: 32350074 

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

Huot N, Rascle P, Petitdemange C, Contreras V, Stürzel CM, Baquero E, Harper JL, Passaes C, Legendre R, Varet H, Madec Y, Sauermann U, Stahl-Hennig C, Nattermann J, Saez-Cirion A, Le Grand R, Keith Reeves R, Paiardini M, Kirchhoff F, Jacquelin B, Müller-Trutwin M. Nat Commun. 2021 Feb 24;12(1):1282. doi: 10.1038/s41467-021-21402-1.PMID: 33627642

Role of NKG2a/c+ CD8 + T cells in pathogenic versus non-pathogenic SIV infections

Huot N, Rascle P, Tchitchek N, Wimmer B, Passaes C, Contreras V, Desjardins D, Stahl-Hennig C, Le Grand R, Saez-Cirion A, Jacquelin B, Müller-Trutwin M. iScience. 2021 Mar 15;24(4):102314. doi: 10.1016/j.isci.2021.102314. PMID: 33870131

Ultrasensitive Detection of p24 in Plasma Samples from People with Primary and Chronic HIV-1 Infection

Passaes C, Delagreverie HM, Avettand-Fenoel V, David A, Monceaux V, Essat A, Müller-Trutwin M, Duffy D, De Castro N, Wittkop L, Rouzioux C, Molina JM, Meyer L, Delaugerre C, Sáez-Cirión A. J Virol. 2021 Jun 24;95(14):e0001621. doi: 10.1128/JVI.00016-21. PMID: 33952636 

CD32+CD4+ T Cells Sharing B Cell Properties Increase With Simian Immunodeficiency Virus Replication in Lymphoid Tissues

Huot N, Rascle P, Planchais C, Contreras V, Passaes C, Le Grand R, Beignon AS, Kornobis E, Legendre R, Varet H, Saez-Cirion A, Mouquet H, Jacquelin B, Müller-Trutwin M. Front Immunol. 2021 Jun 16;12:695148. doi: 10.3389/fimmu.2021.695148. PMID: 34220857 

Optimal Maturation of the SIV-Specific CD8 + T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study

Passaes C, Millet A, Madelain V, Monceaux V, David A, Versmisse P, Sylla N, Gostick E, Llewellyn-Lacey S, Price DA, Blancher A, Dereuddre-Bosquet N, Desjardins D, Pancino G, Le Grand R, Lambotte O, Müller-Trutwin M, Rouzioux C, Guedj J, Avettand-Fenoel V, Vaslin B, Sáez-Cirión A. Cell Rep. 2020 Sep 22;32(12):108174. doi: 10.1016/j.celrep.2020.108174. PMID: 32966788.

Metabolic plasticity of HIV-specific CD8 + T cells is associated with enhanced antiviral potential and natural control of HIV-1 infection

Angin M, Volant S, Passaes C, Lecuroux C, Monceaux V, Dillies MA, Valle-Casuso JC, Pancino G, Vaslin B, Le Grand R, Weiss L, Goujard C, Meyer L, Boufassa F, Müller-Trutwin M, Lambotte O, Sáez-Cirión A. Nat Metab. 2019 Jul;1(7):704-716. doi: 10.1038/s42255-019-0081-4. Epub 2019 Jul 12. PMID: 32694646.

The Yellow Brick Road towards HIV Eradication

Saez-Cirion A, Müller-Trutwin M. Trends Immunol. 2019 Jun;40(6):465-467. doi: 10.1016/j.it.2019.04.006. Epub 2019 May 6. PMID: 31072685.

Cellular Metabolism Is a Major Determinant of HIV-1 Reservoir Seeding in CD4 + T Cells and Offers an Opportunity to Tackle Infection

Valle-Casuso JC, Angin M, Volant S, Passaes C, Monceaux V, Mikhailova A, Bourdic K, Avettand-Fenoel V, Boufassa F, Sitbon M, Lambotte O, Thoulouze MI, Müller-Trutwin M, Chomont N, Sáez-Cirión A. Cell Metab. 2019 Mar 5;29(3):611-626.e5. doi: 10.1016/j.cmet.2018.11.015. Epub 2018 Dec 20. PMID: 30581119.

Ultrasensitive HIV-1 p24 Assay Detects Single Infected Cells and Differences in Reservoir Induction by Latency Reversal Agents

Passaes CPB, Bruel T, Decalf J, David A, Angin M, Monceaux V, Muller-Trutwin M, Noel N, Bourdic K, Lambotte O, Albert ML, Duffy D, Schwartz O, Sáez-Cirión A. J Virol. 2017 Feb 28;91(6):e02296-16. doi: 10.1128/JVI.02296-16. PMID: 28077644; PMCID: PMC5331803.

Early antiretroviral therapy favors post-treatment SIV control associated with the expansion of enhanced memory CD8+ T-cells

Passaes C, Desjardins D, Chapel A, Monceaux V, Lemaitre J, Mélard A, Perdomo-Celis F, Planchais C, Gourvès M, Dimant N, David A, Dereuddre-Bosquet N, Barrail-Tran A, Gouget H, Guillaume C, Relouzat F, Lambotte O, Guedj J, Müller-Trutwin M, Mouquet H, Rouzioux C, Avettand-Fenoël V, Le Grand R, Sáez-Cirión A.

Nature Communications. 2024, 15(1), Article number: 178