About

Clinical researcher at Centre Hospitalier Régional D’Orléans – Service Des Maladies Infectieuses Et Tropicales. His research focuses on understanding the HIV-infection pathogenesis, characterization of HIV reservoirs, antiretroviral, characterization of Viro-immunological response following HIV infection, mechanisms underlying HIV-1 control in Post-Treatment Controllers (PTCs) and HIV-cure related therapeutic clinical trials.

Position
Clinician
Institution
Centre Hospitalier Régional D'Orléans
Website
https://www.chr-orleans.fr/

Linked Projects

Funded Research Project

Title: Viral dynamics of rebound and control following early treatment of HIV/SIV (NIH)

The results of the ANRS EP47 VISCONTI (Viro-Immunological Sustained COntrol after Treatment Interruption) study provided proof of concept that a state of sustainable HIV remission may be induced in at least some people with HIV: the post-treatment controllers (PTC). Unlike natural controllers, PTCs presented a symptomatic primary HIV-1 infection with high viral load and low… Continue reading Viral dynamics of rebound and control following early treatment of HIV/SIV (NIH)

Country
France
Starting year
2017
Duration
5 years
Budget
1.1M$
Members/PIs involved

Asier Sáez-Cirión

Researcher - Institut Pasteur

Christine Rouzioux

Researcher - Paris-Descartes University

Véronique Avettand-Fènoël

Researcher - Medical virologist - Institut Cochin - CNRS 8104 / INSERM U1016 / Université Paris Cité

Hugo Mouquet

Researcher - Institut Pasteur

Jérémie Guedj

Researcher - French Institute of Health & Medical Research (Inserm)

Michaela Müller-Trutwin

Researcher - Institut Pasteur

Laurence Meyer

Researcher - Université Paris-Saclay & APHP

Laurent Hocqueloux

Clinician - Centre Hospitalier Régional D'Orléans
Read more

Linked Publications

Anti-V1/V3-glycan broadly HIV-1 neutralizing antibodies in a post-treatment controller

Molinos-Albert LM, Baquero E, Bouvin-Pley M, Lorin V, Charre C, Planchais C, Dimitrov JD, Monceaux V, Vos M, Hocqueloux L, Berger J-L, Seaman MS, Braibant M, Avettand-Fenoël V, Sáez-Cirión A, Mouquet H

Cell Host Microbe. 2023 Aug 9;31(8):1275-1287.e8
In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control

Trémeaux P, Lemoine F, Mélard A, Gousset M, Boufassa F, Orr S, Monceaux V, Gascuel O, Lambotte O, Hocqueloux L, Saez-Cirion A, Rouzioux C, Avettand-Fenoel V.

Microbiol Spectr. 2023 Jan 24:e0326722.
Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications

Avettand-Fènoël V, Hocqueloux L, Ghosn J, Cheret A, Frange P, Melard A, Viard JP, Rouzioux C. Clin Microbiol Rev. 2016 Oct;29(4):859-80. doi: 10.1128/CMR.00015-16. PMID: 27559075; PMCID: PMC5010749.
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study

Sáez-Cirión A, Bacchus C, Hocqueloux L, Avettand-Fenoel V, Girault I, Lecuroux C, Potard V, Versmisse P, Melard A, Prazuck T, Descours B, Guergnon J, Viard JP, Boufassa F, Lambotte O, Goujard C, Meyer L, Costagliola D, Venet A, Pancino G, Autran B, Rouzioux C; ANRS VISCONTI Study Group. PLoS Pathog. 2013 Mar;9(3):e1003211. doi: 10.1371/journal.ppat.1003211. Epub 2013 Mar 14. PMID: 23516360; PMCID: PMC3597518.
Transient viral exposure drives functionally-coordinated humoral immune responses in HIV-1 post-treatment controllers

Molinos-Albert LM, Lorin V, Monceaux V, Orr S, Essat A, Dufloo J, Schwartz O, Rouzioux C, Meyer L, Hocqueloux L, Sáez-Cirión A, Mouquet H & ANRS VISCONTI Study Group

Nature Communications Vol 13 : 1944 (2022)
Long-term antiretroviral therapy initiated during primary HIV-1 infection is key to achieving both low HIV reservoirs and normal T cell counts

Hocqueloux L, Avettand-Fènoël V, Jacquot S, Prazuck T, Legac E, Mélard A, Niang M, Mille C, Le Moal G, Viard JP, Rouzioux C; AC32 (Coordinated Action on HIV Reservoirs) of the Agence Nationale de Recherches sur le Sida et les Hépatites Virales (ANRS). J Antimicrob Chemother. 2013 May;68(5):1169-78. doi: 10.1093/jac/dks533. Epub 2013 Jan 20. PMID: 23335199.